Thermo Fisher Scientific
CarrierMax™ SMN1/SMN2
The CarrierMax SMN1/SMN2 Reagent Kit uses multiplex PCR amplification of genomic DNA and capillary electrophoresis to detect deletions in exon 7 of the Survival of Motor Neuron 1 (SMN1) gene that result in truncated SMN protein. In addition, the kit detects two variants associated with the silent carrier (2+0) haplotype. The results are processed with GeneMapper Software in conjunction with included CarrierMAX Software to consolidate data and simplify carrier classifications in spinal muscular atrophy (SMA) carrier screening research.
CarrierScan – Expanded Carrier Screening
CarrierScan Assay is an innovative, comprehensive, and high-throughput microarray-based tool for the reliable and robust detection of sequence and structural variation for preconception expanded carrier screening research across a wide range of ethnicities. The unique feature of this tool is the ability to consolidate multiple copy number and genotyping tests into a single molecular assay. With simple data analysis and reporting software included in the complete solution, high-throughput molecular labs can generate all relevant carrier screening research data quickly. The complete CarrierScan Assay solution offers flexibility and scalability to meet the changing needs of high-throughput molecular research labs.
CytoScan 750
CytoScan 750K Suite enables cytogenetic researchers to detect and analyze relevant chromosomal aberrations with confidence. CytoScan 750K Suite provides high-resolution coverage of cancer and constitutional genes of interest, along with high-density SNP coverage for loss of heterozygosity (LOH) detection.
Cytoscan HD
CytoScan HD Suite provides the broadest coverage and highest performance for detecting chromosomal aberrations. CytoScan HD Suite has greater than 99% sensitivity and can reliably detect 25-50kb copy number changes across the genome at high specificity with single-nucleotide polymorphism (SNP) allelic corroboration. With more than 2.6 million copy number markers, CytoScan HD Suite covers all OMIM™ and RefSeq genes.Our proprietary manufacturing technology produces arrays that are highly reproducible between each batch with no risk of probe dropout inherent in bead manufacturing techniques. Surpassing the limitations of current database curations, the whole-genome array ensures that novel findings can be catalogued for future discoveries and annotations, which are often missed by targeted designs
CarrierMax™ FMR1
The CarrierMax FMR1 Reagent Kit is used to detect the number of CGG repeats in the Fragile X Mental Retardation (FMR1) gene. This kit uses a dual PCR system combining full length and triplet primed PCR amplification (TP-PCR), followed by fragment analysis on the Applied Biosystems 3500/3500xL Genetic Analyzer or SeqStudio Genetic Analyzer, to accurately determine up to 200 CGG repeats and detect alleles that are >200 CGG repeats.
Cytoscan HT-CMA
The CytoScan HT-CMA assay enables cytogenetic researchers to detect and analyze relevant chromosomal aberrations with confidence. The assay provides high-resolution coverage of OMIM and DECIPHER genes, along with high-density SNP coverage for loss of heterozygosity (LOH) and UPD detection. The CytoScan HT-CMA assay also includes up to 178 relevant single nucleotide variants (SNV) and content for analysis of SMN1, which allows for consolidation of testing.
Genotyping
Agrigenomic microarray genotyping solutions provide breeders and researchers with powerful and flexible genotyping tools to cost-effectively identify, validate, and screen complex genetic traits in plants and animals. Thermo Fisher Scientific’s broad microarray portfolio of robust, accurate, customizable, and scalable genomic testing products facilitates high-throughput routine screening, marker-assisted selection, genome-wide association studies, quantitative trait loci analyses, parentage, and traceability, all of which help fast-track your genomic selection programs. From plants, livestock, aquaculture, and poultry to companion animals, our microarray technology can provide solutions to meet your everchanging needs.
Gene Expression
Transcriptome-wide analysis arrays
From A-Z (Arabidopsis to Zebra fish).
Expression microarrays simultaneously measure expression levels of thousands of RNA transcripts, Isoforms and miRNA.